Having been recently dumped for the nineteenth time by a girl named Katherine, recent high school graduate and former child prodigy Colin sets off on a road trip with his best friend to try to find some new direction in life while also trying to create a mathematical formula to explain his relationships.

Sixteen-year-old Hazel, a stage IV thyroid cancer patient, has accepted her terminal diagnosis until a chance meeting with a boy at cancer support group forces her to reexamine her perspective on love, loss, and life. Despite the tumor-shrinking medical miracle that has bought her a few years, Hazel has never been anything but terminal, her final chapter inscribed upon diagnosis. But when a gorgeous plot twist named Augustus Waters suddenly appears...